The Molecular Biology of Baculoviruses PDF Download. Download free ebook of The Molecular Biology of Baculoviruses in PDF format or read online by Walter Doerfler,Petra Böhm Published on 1986-01-01 by Springer
The pathology caused by baculoviruses in insect popula\u00ad tions was described centuries ago, notably in the larvae of insects such as the silkworm (Bombyx mori) which has been appreciated for the quality and beauty of its products. In the 1940s baculoviruses and their structure and physiolo\u00ad gy were intensively investigated, particularly by Bergold's group in Tiibingen. The following decades saw excellent progress, laying a solid virological base for later investiga\u00ad tions on the system. Further studies mushroomed in the 1970s with the advent of tissue culture systems for insect cells which eventually facilitated the molecular biological approach that came to the fore in the 1980 s. One of the reasons for pursuing research on the baculo\u00ad virus system was the prospect of eventually using these vi\u00ad ruses as insect pest control agents. While this practical as\u00ad pect may appeal to many, molecular biologists had addi\u00ad tional reasons to be interested in baculoviruses. Here was a large DNA viral genome, probably fraught with problems of replication and regulation that hopefully would open inroads into the molecular biology of interesting insect cell systems. In the days when genetechnology promises laurels, and after several virus systems had been skilfully exploited as highly efficient eukaryotic expression vectors, it came as no surprise that baculoviruses were also investigated in that respect. Indeed, the Autographa californica nuclear po\u00ad lyhedrosis virus became a good vector. Insect cells also seem to collaborate in modifying and processing the gene\u00ad technologically synthesized polypeptides.
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